Personally I don't run ANY popup blockers; IE is well equipped to do this, plus the two good free toolbars - Yahoo and Google each have a free popup blocker to use along side IE. As for Malwarebytes, there seems to some praise heaped upon this program........... still, I wouldn't touch it yet; however others may have more information.
Zone Alarm Pro is AV and Firewall, but costs $$$; Zone Alarm Free is a free firewall and Avast! is free AV, both will work together. AVG free is also a good AV program for PC's with less resources (RAM)
Spybot S & D is still a good program; just make sure to keep it up to date; CCleaner is excellent replacement program for Windows hard drive cleanup.
On a KNOWN CLEAN system, Spywareblaster is also a (Free) good thing to have, as it uses known database of exploits to tweak your IE and network settings; however, if your system is already suspect for infection, us AV on AV online scanners to clean your system, as Spyware blaster doesn't "find" spyware or malicious programs, it just prevents your system from being exploited.